Progress of Folic Acid-Folate Receptor as Drug Carriers in Targeted Drug Delivery System
نویسندگان
چکیده
Targeted drug delivery system is an effective method for the diagnosis and treatment of cancer, it has received much attention because its low side effects therapeutic efficacy. Folic acid receptor highly expressed on surface most cancer cells, but or not normal ligand folate a high affinity. attached to carriers can be targeted cells. This paper introduces folic receptors, briefly describes mechanism action receptor-mediated delivery, discusses progress four types acid-folate treatment: acid-conjugated magnetic nanoparticles, binding small-molecule acid, receptor-bound protein, polysialic acid. It also analyzes favorable points future development trends each mechanism.
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ژورنال
عنوان ژورنال: SHS web of conferences
سال: 2022
ISSN: ['2261-2424', '2416-5182']
DOI: https://doi.org/10.1051/shsconf/202214401002